![]() Conversely it may be decreased in dehydration. Volume of distribution may be increased by renal failure and liver failure. In rough terms, drugs with high lipid solubility, low rates of ionization or low plasma binding capabilities have higher volumes of distribution than drugs which are more polar, more highly ionized or exhibit high plasma binding in the body's environment. It is defined as the theoretical volume in which the total amount of drug would need to be uniformly distributed to produce the desired blood concentration of a drug. It is defined as the distribution of a medication between plasma and the rest of the body after oral or parenteral dosing. Therefore, if VD is greater, it shows that the drug is more diluted than it should be, meaning more of it is distributed in tissue. Volume of distribution of drugs: an apparent data in pharmacology Once the drug has been given and reaches the vascular system of the patient, some drugs are distributed only to the body fluids (plasma plus extracellular water), while others are bound extensively in body tissues. The volume of distribution, also known as apparent volume of distribution, is a pharmacological, theoretical volume that the total amount of administered drug would have to occupy, to provide the same concentration as it currently is in blood plasma. ![]() Freebase (0.00 / 0 votes) Rate this definition:
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